(2-CHLOROPYRIDYL)-5-ACETIC ACID
6-Chloro-3-pyridineacetic acid
CAS: 39891-13-9
Molecular Formula: C7H6ClNO2
(2-CHLOROPYRIDYL)-5-ACETIC ACID - Names and Identifiers
| Name | 6-Chloro-3-pyridineacetic acid |
| Synonyms | 6-Chloro-3-pyridylacetic acid 6-Chloro-3-pyridineacetic acid 2-Chloropyridine-5-acetic acid 2-CHLOROPYRIDINE-5-ACETIC ACID 6-CHLOROPYRIDINE-3-ACETIC ACID (2-CHLOROPYRIDYL)-5-ACETIC ACID 3-Pyridineacetic acid, 6-chloro- (6-Chloropyridin-3-yl)acetic acid (6-CHLORO-PYRIDIN-3-YL)-ACETIC ACID 2-(2-Chloropyridin-5-yl)acetic acid 2-(6-CHLOROPYRIDIN-3-YL)ACETIC ACID |
| CAS | 39891-13-9 |
| EINECS | 670-360-7 |
| InChI | InChI=1/C7H6ClNO2/c8-6-2-1-5(4-9-6)3-7(10)11/h1-2,4H,3H2,(H,10,11) |
(2-CHLOROPYRIDYL)-5-ACETIC ACID - Physico-chemical Properties
| Molecular Formula | C7H6ClNO2 |
| Molar Mass | 171.58 |
| Density | 1.405±0.06 g/cm3(Predicted) |
| Melting Point | 164-169°C |
| Boling Point | 336.6±27.0 °C(Predicted) |
| Flash Point | 157.378°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 3.91±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.575 |
| MDL | MFCD01863172 |
(2-CHLOROPYRIDYL)-5-ACETIC ACID - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Hazard Class | IRRITANT |
(2-CHLOROPYRIDYL)-5-ACETIC ACID - Reference Information
| Use | (6-chloro-pyridine 3-yl) acetic acid is a nitrogen-containing heterocyclic fatty acid. Nitrogen-containing heterocyclic fatty acids play an important role in drug synthesis research, such as ibuprofen and indole acetic acid, which have been used as drugs. |
| a synthesis method for preparing | (6-chloro-pyridine 3-yl) acetic acid, comprising the following steps: S1: adding 8.72 mmol2-chloro -5-chloromethylpyridine catalyst and solvent DMF into a reaction kettle; S2: adding carbon dioxide to make the pressure in the kettle 3MPa, the adjustment reaction was carried out at 40 ℃ for 15 hours. S3: In the reaction kettle to add dilute hydrochloric acid acidification, ethyl acetate extraction, combined organic phase, rotary evaporation to remove the liquid, further vacuum drying, to obtain (6-chloro-pyridine 3-yl) acetic acid. The catalyst includes zinc powder and lithium chloride, chloromethyl heterocyclic compound and zinc powder, the molar ratio of lithium chloride added to the reaction kettle is 1:3, and 2.8-2.9ml of solvent DMF is added to each mmol2-chloro-5-chloromethylpyridine. |
Last Update：2024-04-09 15:16:36
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